A Bitot’s Spot is an area on the white part of the eye that doesn’t wet well and appears keratinized. It is often associated with vitamin A deficiency. It is fairly asymptomatic and patients are unaware they have it when it is discovered. Vitamin A deficiency happens mostly in children in developing countries, but we often see it in college kids for various reasons (including malnutrition and alcohol consumption). Bitot’s Spot is often one of the first signs of Vitamin A deficiency. Advanced deficiency can lead to night blindness.